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Characterization of the 1918 influenza virus hemagglutinin and neuraminidase genes

Identifieur interne : 001849 ( Main/Exploration ); précédent : 001848; suivant : 001850

Characterization of the 1918 influenza virus hemagglutinin and neuraminidase genes

Auteurs : Jeffery K. Taubenberger [États-Unis] ; Ann H. Reid [États-Unis] ; Thomas A. Janczewski [États-Unis] ; Thomas G. Fanning [États-Unis]

Source :

RBID : ISTEX:5E20E5B765D62D2CE07D23506FBC9DF1A700A6F4

English descriptors

Abstract

Abstract: In the fall and winter of 1918–1919, an influenza pandemic of unprecedented virulence swept the globe leaving 40 million or more dead in its wake. The virus responsible for this catastrophe was not isolated at the time, however, it has recently become possible to study the genetic features of the 1918 ‘Spanish’ influenza virus using frozen and fixed autopsy tissue. Gene sequences of the 1918 virus can be used to frame hypotheses about the origin of the 1918 virus, and to look for clues to its virulence. The study of the 1918 virus is not just one of historical curiosity. An understanding of the genetic make-up of the most virulent influenza strain in history may facilitate prediction and prevention of future pandemics.

Url:
DOI: 10.1016/S0531-5131(01)00629-X


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<div type="abstract" xml:lang="en">Abstract: In the fall and winter of 1918–1919, an influenza pandemic of unprecedented virulence swept the globe leaving 40 million or more dead in its wake. The virus responsible for this catastrophe was not isolated at the time, however, it has recently become possible to study the genetic features of the 1918 ‘Spanish’ influenza virus using frozen and fixed autopsy tissue. Gene sequences of the 1918 virus can be used to frame hypotheses about the origin of the 1918 virus, and to look for clues to its virulence. The study of the 1918 virus is not just one of historical curiosity. An understanding of the genetic make-up of the most virulent influenza strain in history may facilitate prediction and prevention of future pandemics.</div>
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